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FOXP3+ regulatory T cells and their functional regulation #MMPMID25683611
Li Z; Li D; Tsun A; Li B
Cell Mol Immunol 2015[Sep]; 12 (5): 558-65 PMID25683611show ga
FOXP3+ regulatory T (Treg) cells are critical in maintaining immune tolerance and homeostasis of the immune system. The molecular mechanisms underlying the stability, plasticity and functional activity of Treg cells have been much studied in recent years. Here, we summarize these intriguing findings, and provide insight into their potential use or manipulation during Treg cell therapy for the treatment of autoimmune diseases, graft-versus-host disease (GVHD) and cancer.