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10.1038/aps.2014.117 http://scihub22266oqcxt.onion/10.1038/aps.2014.117 C4571316!4571316!25500874     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25500874.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Acta+Pharmacol+Sin 2015 ; 36 (1): 37-43 Nephropedia Template TP {{tp|p=25500874|t=2015. FXR and liver carcinogenesis |pdf=|usr=}}{{25500874}} gab.com Text FXR and liver carcinogenesis JO: Acta Pharmacol Sin http://www.kidney.de/pget.php?&tw=1&pmid=25500874 #FOAvip Farnesoid X receptor (FXR) is a member of the nuclear receptor family and a ligand-modulated transcription factor. In the liver, FXR has been considered a multi-functional cell protector and a tumor suppressor. FXR can suppress liver carcinogenesis via different mechanisms: 1) FXR maintains the normal liver metabolism of bile acids, glucose and lipids; 2) FXR promotes liver regeneration and repair after injury; 3) FXR protects liver cells from death and enhances cell survival; 4) FXR suppresses hepatic inflammation, thereby preventing inflammatory damage; and 5) FXR can directly increase the expression of some tumor-suppressor genes and repress the transcription of several oncogenes. However, inflammation and epigenetic silencing are known to decrease FXR expression during tumorigenesis. The reactivation of FXR function in the liver may be a potential therapeutic approach for patients with liver cancer. Twit Text FOAVip FXR and liver carcinogenesis ????Acta Pharmacol Sin http://www.kidney.de/pget.php?&tw=1&pmid=25500874 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25500874 #FOAvip English Wikipedia <ref>{{Cite pmid|25500874}}</ref> FXR and liver carcinogenesis #MMPMID25500874 Huang Xf; Zhao Wy; Huang Wd Acta Pharmacol Sin 2015[Jan]; 36 (1): 37-43 PMID25500874show ga Farnesoid X receptor (FXR) is a member of the nuclear receptor family and a ligand-modulated transcription factor. In the liver, FXR has been considered a multi-functional cell protector and a tumor suppressor. FXR can suppress liver carcinogenesis via different mechanisms: 1) FXR maintains the normal liver metabolism of bile acids, glucose and lipids; 2) FXR promotes liver regeneration and repair after injury; 3) FXR protects liver cells from death and enhances cell survival; 4) FXR suppresses hepatic inflammation, thereby preventing inflammatory damage; and 5) FXR can directly increase the expression of some tumor-suppressor genes and repress the transcription of several oncogenes. However, inflammation and epigenetic silencing are known to decrease FXR expression during tumorigenesis. The reactivation of FXR function in the liver may be a potential therapeutic approach for patients with liver cancer. äFXR and liver carcinogenesis (epmc).pdf DeepDyve Pubget Overpricing