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10.1016/j.kint.2016.08.013 http://scihub22266oqcxt.onion/10.1016/j.kint.2016.08.013 C5914485!5914485!27742194     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27742194.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Kidney+Int 2016 ; 90 (5): 928-30 Nephropedia Template TP {{tp|p=27742194|t=2016. Fibroblast growth factor 23: fueling the fire |pdf=|usr=}}{{27742194}} gab.com Text Fibroblast growth factor 23: fueling the fire JO: Kidney Int http://www.kidney.de/pget.php?&tw=1&pmid=27742194 #FOAvip In chronic kidney disease, systemic inflammation is common and associated with mortality. The present study demonstrates that fibroblast growth factor 23 (FGF23) contributes to uremic inflammation by increasing hepatic expression and secretion of inflammatory cytokines. FGF23 binds to hepatic FGFR4, inducing calcineurin/nuclear factor of activated T-cell signaling, resulting in increased expression of interleukin 6 and C-reactive protein. The proinflammatory effects of FGF23 are inhibited by an isoform-specific FGFR4 blocking antibody and by cyclosporine, a calcineurin inhibitor. Twit Text FOAVip Fibroblast growth factor 23: fueling the fire ????Kidney Int http://www.kidney.de/pget.php?&tw=1&pmid=27742194 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27742194 #FOAvip English Wikipedia <ref>{{Cite pmid|27742194}}</ref> Fibroblast growth factor 23: fueling the fire #MMPMID27742194 Hanudel M; Jüppner H; Salusky IB Kidney Int 2016[Nov]; 90 (5): 928-30 PMID27742194show ga In chronic kidney disease, systemic inflammation is common and associated with mortality. The present study demonstrates that fibroblast growth factor 23 (FGF23) contributes to uremic inflammation by increasing hepatic expression and secretion of inflammatory cytokines. FGF23 binds to hepatic FGFR4, inducing calcineurin/nuclear factor of activated T-cell signaling, resulting in increased expression of interleukin 6 and C-reactive protein. The proinflammatory effects of FGF23 are inhibited by an isoform-specific FGFR4 blocking antibody and by cyclosporine, a calcineurin inhibitor. äFibroblast growth factor 23: fueling the fire (epmc).pdf DeepDyve Pubget Overpricing