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10.1146/annurev-biophys-050511-102252 http://scihub22266oqcxt.onion/10.1146/annurev-biophys-050511-102252 C5508560!5508560!22404683     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=22404683&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\22404683.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Annu+Rev+Biophys 2012 ; 41 (ä): 227-46 Nephropedia Template TP {{tp|p=22404683|t=2012. Filamins in mechanosensing and signaling |pdf=|usr=}}{{22404683}} gab.com Text Filamins in mechanosensing and signaling JO: Annu Rev Biophys http://www.kidney.de/pget.php?&tw=1&pmid=22404683 #FOAvip Filamins are essential, evolutionary conserved, modular, multi-domain, actin-binding proteins that organize the actin cytoskeleton and maintain extracellular matrix connections by anchoring actin filaments to transmembrane receptors. By crosslinking and anchoring actin filaments, filamins stabilize the plasma membrane, provide cellular cortical rigidity and contribute to the mechanical stability of the plasma membrane and the cell cortex. In addition to actin, filamins interact with over 90 other binding partners including intracellular signaling molecules, receptors, ion channels, transcriptions factors and cytoskeletal and adhesion proteins. Thus, filamins scaffold a wide range of signaling pathways and are implicated in the regulation of a diverse array of cellular functions including motility, maintenance of cell shape and differentiation. Here, we review emerging structural and functional evidence that filamins are mechanosensors and/or mechanotransducers, playing essential roles in helping cells to detect and respond to physical forces in their local environment. Twit Text FOAVip Filamins in mechanosensing and signaling ????Annu Rev Biophys http://www.kidney.de/pget.php?&tw=1&pmid=22404683 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=22404683 #FOAvip English Wikipedia <ref>{{Cite pmid|22404683}}</ref> Filamins in mechanosensing and signaling #MMPMID22404683 Razinia Z; Mäkelä T; Ylänne J; Calderwood DA Annu Rev Biophys 2012[]; 41 (ä): 227-46 PMID22404683show ga Filamins are essential, evolutionary conserved, modular, multi-domain, actin-binding proteins that organize the actin cytoskeleton and maintain extracellular matrix connections by anchoring actin filaments to transmembrane receptors. By crosslinking and anchoring actin filaments, filamins stabilize the plasma membrane, provide cellular cortical rigidity and contribute to the mechanical stability of the plasma membrane and the cell cortex. In addition to actin, filamins interact with over 90 other binding partners including intracellular signaling molecules, receptors, ion channels, transcriptions factors and cytoskeletal and adhesion proteins. Thus, filamins scaffold a wide range of signaling pathways and are implicated in the regulation of a diverse array of cellular functions including motility, maintenance of cell shape and differentiation. Here, we review emerging structural and functional evidence that filamins are mechanosensors and/or mechanotransducers, playing essential roles in helping cells to detect and respond to physical forces in their local environment. äFilamins in mechanosensing and signaling (epmc).pdf DeepDyve Pubget Overpricing