Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1038/cddis.2015.396 http://scihub22266oqcxt.onion/10.1038/cddis.2015.396 C4816178!4816178!26764572     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26764572&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26764572.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cell+Death+Dis 2016 ; 7 (1): e2046- Nephropedia Template TP {{tp|p=26764572|t=2016. FoxO3 suppresses Myc-driven lymphomagenesis |pdf=|usr=}}{{26764572}} gab.com Text FoxO3 suppresses Myc-driven lymphomagenesis JO: Cell Death Dis http://www.kidney.de/pget.php?&tw=1&pmid=26764572 #FOAvip This study demonstrates, for the first time, that loss of a single forkhead box class O (FoxO) transcription factor, can promote lymphomagenesis. Using two different mouse models, we show that FoxO3 has a significant tumour-suppressor function in the context of Myc-driven lymphomagenesis. Loss of FoxO3 significantly accelerated myeloid tumorigenesis in vavP-MYC10 transgenic mice and B lymphomagenesis in E?-myc transgenic mice. Tumour analysis indicated that the selective pressure for mutation of the p53 pathway during E?-myc lymphomagenesis was not altered. Frank tumours were preceded by elevated macrophage numbers in FoxO3?/? vavP-MYC10 mice but, surprisingly, pre-B-cell numbers were relatively normal in healthy young FoxO3?/?E?-myc mice. In vitro assays revealed enhanced survival capacity of Myc-driven cells lacking FoxO3, but no change in cell cycling was detected. The loss of FoxO3 may also be affecting other tumour-suppressive functions for which FoxO1/4 cannot fully compensate. Twit Text FOAVip FoxO3 suppresses Myc-driven lymphomagenesis ????Cell Death Dis http://www.kidney.de/pget.php?&tw=1&pmid=26764572 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26764572 #FOAvip English Wikipedia <ref>{{Cite pmid|26764572}}</ref> FoxO3 suppresses Myc-driven lymphomagenesis #MMPMID26764572 Vandenberg CJ; Motoyama N; Cory S Cell Death Dis 2016[Jan]; 7 (1): e2046- PMID26764572show ga This study demonstrates, for the first time, that loss of a single forkhead box class O (FoxO) transcription factor, can promote lymphomagenesis. Using two different mouse models, we show that FoxO3 has a significant tumour-suppressor function in the context of Myc-driven lymphomagenesis. Loss of FoxO3 significantly accelerated myeloid tumorigenesis in vavP-MYC10 transgenic mice and B lymphomagenesis in E?-myc transgenic mice. Tumour analysis indicated that the selective pressure for mutation of the p53 pathway during E?-myc lymphomagenesis was not altered. Frank tumours were preceded by elevated macrophage numbers in FoxO3?/? vavP-MYC10 mice but, surprisingly, pre-B-cell numbers were relatively normal in healthy young FoxO3?/?E?-myc mice. In vitro assays revealed enhanced survival capacity of Myc-driven cells lacking FoxO3, but no change in cell cycling was detected. The loss of FoxO3 may also be affecting other tumour-suppressive functions for which FoxO1/4 cannot fully compensate. äFoxO3 suppresses Myc-driven lymphomagenesis (epmc).pdf DeepDyve Pubget Overpricing