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10.1038/nn.3954

http://scihub22266oqcxt.onion/10.1038/nn.3954
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C4444366!4444366!25706471
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suck abstract from ncbi


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pmid25706471      Nat+Neurosci 2015 ; 18 (4): 576-81
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  • Frequency-specific hippocampal-prefrontal interactions during associative learning #MMPMID25706471
  • Brincat SL; Miller EK
  • Nat Neurosci 2015[Apr]; 18 (4): 576-81 PMID25706471show ga
  • Much of our knowledge of the world depends on learning associations (e.g., face-name), for which the hippocampus (HPC) and prefrontal cortex (PFC) are critical. HPC-PFC interactions have rarely been studied in monkeys, whose cognitive/mnemonic abilities are akin to humans. Here, we show functional differences and frequency-specific interactions between HPC and PFC of monkeys learning object-pair associations, an animal model of human explicit memory. PFC spiking activity reflected learning in parallel with behavioral performance, while HPC neurons reflected feedback about whether trial-and-error guesses were correct or incorrect. Theta-band HPC-PFC synchrony was stronger after errors, was driven primarily by PFC to HPC directional influences, and decreased with learning. In contrast, alpha/beta-band synchrony was stronger after correct trials, was driven more by HPC, and increased with learning. Rapid object associative learning may occur in PFC, while HPC may guide neocortical plasticity by signaling success or failure via oscillatory synchrony in different frequency bands.
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