Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1186/s13059-017-1181-7 http://scihub22266oqcxt.onion/10.1186/s13059-017-1181-7 C5376702!5376702!28366169     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28366169&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28366169.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Genome+Biol 2017 ; 18 (ä): ä Nephropedia Template TP {{tp|p=28366169|t=2017. Functional implications of Neandertal introgression in modern humans |pdf=|usr=}}{{28366169}} gab.com Text Functional implications of Neandertal introgression in modern humans JO: Genome Biol http://www.kidney.de/pget.php?&tw=1&pmid=28366169 #FOAvip Background: Admixture between early modern humans and Neandertals approximately 50,000?60,000 years ago has resulted in 1.5?4% Neandertal ancestry in the genomes of present-day non-Africans. Evidence is accumulating that some of these archaic alleles are advantageous for modern humans, while others are deleterious; however, the major mechanism by which these archaic alleles act has not been fully explored. Results: Here we assess the contributions of introgressed non-synonymous and regulatory variants to modern human protein and gene expression variation. We show that gene expression changes are more often associated with Neandertal ancestry than expected, and that the introgressed non-synonymous variants tend to have less predicted functional effect on modern human proteins than mutations that arose on the human lineage. Conversely, introgressed alleles contribute proportionally more to expression variation than non-introgressed alleles. Conclusions: Our results suggest that the major influence of Neandertal introgressed alleles is through their effects on gene regulation. Electronic supplementary material: The online version of this article (doi:10.1186/s13059-017-1181-7) contains supplementary material, which is available to authorized users. Twit Text FOAVip Functional implications of Neandertal introgression in modern humans ????Genome Biol http://www.kidney.de/pget.php?&tw=1&pmid=28366169 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28366169 #FOAvip English Wikipedia <ref>{{Cite pmid|28366169}}</ref> Functional implications of Neandertal introgression in modern humans #MMPMID28366169 Dannemann M; Prüfer K; Kelso J Genome Biol 2017[]; 18 (ä): ä PMID28366169show ga Background: Admixture between early modern humans and Neandertals approximately 50,000?60,000 years ago has resulted in 1.5?4% Neandertal ancestry in the genomes of present-day non-Africans. Evidence is accumulating that some of these archaic alleles are advantageous for modern humans, while others are deleterious; however, the major mechanism by which these archaic alleles act has not been fully explored. Results: Here we assess the contributions of introgressed non-synonymous and regulatory variants to modern human protein and gene expression variation. We show that gene expression changes are more often associated with Neandertal ancestry than expected, and that the introgressed non-synonymous variants tend to have less predicted functional effect on modern human proteins than mutations that arose on the human lineage. Conversely, introgressed alleles contribute proportionally more to expression variation than non-introgressed alleles. Conclusions: Our results suggest that the major influence of Neandertal introgressed alleles is through their effects on gene regulation. Electronic supplementary material: The online version of this article (doi:10.1186/s13059-017-1181-7) contains supplementary material, which is available to authorized users. äFunctional implications of Neandertal introgression in modern humans (epmc).pdf DeepDyve Pubget Overpricing