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10.1093/nar/gkv862 http://scihub22266oqcxt.onion/10.1093/nar/gkv862 C4605312!4605312!26350216     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26350216.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nucleic+Acids+Res 2015 ; 43 (18): 8627-37 Nephropedia Template TP {{tp|p=26350216|t=2015. G-quadruplexes and their regulatory roles in biology |pdf=|usr=}}{{26350216}} gab.com Text G-quadruplexes and their regulatory roles in biology JO: Nucleic Acids Res http://www.kidney.de/pget.php?&tw=1&pmid=26350216 #FOAvip ?If G-quadruplexes form so readily in vitro, Nature will have found a way of using them in vivo? (Statement by Aaron Klug over 30 years ago).During the last decade, four-stranded helical structures called G-quadruplex (or G4) have emerged from being a structural curiosity observed in vitro, to being recognized as a possible nucleic acid based mechanism for regulating multiple biological processes in vivo. The sequencing of many genomes has revealed that they are rich in sequence motifs that have the potential to form G-quadruplexes and that their location is non-random, correlating with functionally important genomic regions. In this short review, we summarize recent evidence for the in vivo presence and function of DNA and RNA G-quadruplexes in various cellular pathways including DNA replication, gene expression and telomere maintenance. We also highlight remaining open questions that will have to be addressed in the future. Twit Text FOAVip G-quadruplexes and their regulatory roles in biology ????Nucleic Acids Res http://www.kidney.de/pget.php?&tw=1&pmid=26350216 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26350216 #FOAvip English Wikipedia <ref>{{Cite pmid|26350216}}</ref> G-quadruplexes and their regulatory roles in biology #MMPMID26350216 Rhodes D; Lipps HJ Nucleic Acids Res 2015[Oct]; 43 (18): 8627-37 PMID26350216show ga ?If G-quadruplexes form so readily in vitro, Nature will have found a way of using them in vivo? (Statement by Aaron Klug over 30 years ago).During the last decade, four-stranded helical structures called G-quadruplex (or G4) have emerged from being a structural curiosity observed in vitro, to being recognized as a possible nucleic acid based mechanism for regulating multiple biological processes in vivo. The sequencing of many genomes has revealed that they are rich in sequence motifs that have the potential to form G-quadruplexes and that their location is non-random, correlating with functionally important genomic regions. In this short review, we summarize recent evidence for the in vivo presence and function of DNA and RNA G-quadruplexes in various cellular pathways including DNA replication, gene expression and telomere maintenance. We also highlight remaining open questions that will have to be addressed in the future. äG-quadruplexes and their regulatory roles in biology (epmc).pdf DeepDyve Pubget Overpricing