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10.4049/jimmunol.1502643 http://scihub22266oqcxt.onion/10.4049/jimmunol.1502643 C4780223!4780223!26945088     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26945088.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Immunol 2016 ; 196 (6): 2431-7 Nephropedia Template TP {{tp|p=26945088|t=2016. Genetic and epigenetic regulation of PD-1 expression1 |pdf=|usr=}}{{26945088}} gab.com Text Genetic and epigenetic regulation of PD-1 expression1 JO: J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=26945088 #FOAvip The inhibitory immune receptor Programmed cell death-1 (PD-1) is intricately regulated. In T cells, PD-1 is expressed in response to most immune challenges, but is rapidly down regulated in acute settings, allowing for normal immune responses. On chronically stimulated antigen-specific T cells, PD-1 expression remains high, leading to an impaired response to stimuli. Antibody blockade of PD-1 interactions during chronic antigen settings partially restores immune function and is now used clinically to treat a variety of devastating cancers. Understanding the regulation of PD-1 expression may be useful for developing novel immune based therapies. Here, the molecular mechanisms that drive dynamic PD-1 expression during acute and chronic antigenic stimuli are reviewed. An array of cis-DNA elements, transcription factors, and epigenetic components, including DNA methylation and histone modifications, control PD-1 expression. The interplay between these regulators fine-tunes PD-1 expression in different inflammatory environments and across numerous cell types to modulate immune responses. Twit Text FOAVip Genetic and epigenetic regulation of PD-1 expression1 ????J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=26945088 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26945088 #FOAvip English Wikipedia <ref>{{Cite pmid|26945088}}</ref> Genetic and epigenetic regulation of PD-1 expression1 #MMPMID26945088 Bally AP; Austin JW; Boss JM J Immunol 2016[Mar]; 196 (6): 2431-7 PMID26945088show ga The inhibitory immune receptor Programmed cell death-1 (PD-1) is intricately regulated. In T cells, PD-1 is expressed in response to most immune challenges, but is rapidly down regulated in acute settings, allowing for normal immune responses. On chronically stimulated antigen-specific T cells, PD-1 expression remains high, leading to an impaired response to stimuli. Antibody blockade of PD-1 interactions during chronic antigen settings partially restores immune function and is now used clinically to treat a variety of devastating cancers. Understanding the regulation of PD-1 expression may be useful for developing novel immune based therapies. Here, the molecular mechanisms that drive dynamic PD-1 expression during acute and chronic antigenic stimuli are reviewed. An array of cis-DNA elements, transcription factors, and epigenetic components, including DNA methylation and histone modifications, control PD-1 expression. The interplay between these regulators fine-tunes PD-1 expression in different inflammatory environments and across numerous cell types to modulate immune responses. äGenetic and epigenetic regulation of PD-1 expression1 (epmc).pdf DeepDyve Pubget Overpricing