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10.1681/ASN.2015010109 http://scihub22266oqcxt.onion/10.1681/ASN.2015010109 C4769202!4769202!26185202     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26185202.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Am+Soc+Nephrol 2016 ; 27 (3): 933-41 Nephropedia Template TP {{tp|p=26185202|t=2016. Glycosylation Profile of IgG in Moderate Kidney Dysfunction |pdf=|usr=}}{{26185202}} gab.com Text Glycosylation Profile of IgG in Moderate Kidney Dysfunction JO: J Am Soc Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=26185202 #FOAvip Glycans constitute the most abundant and diverse form of the post-translational modifications, and animal studies have suggested the involvement of IgG glycosylation in mechanisms of renal damage. Here, we explored the associations between IgG glycans and renal function in 3274 individuals from the TwinsUK registry. We analyzed the correlation between renal function measured as eGFR and 76 N-glycan traits using linear regressions adjusted for covariates and multiple testing in the larger population. We replicated our results in 31 monozygotic twin pairs discordant for renal function. Results from both analyses were then meta-analyzed. Fourteen glycan traits were associated with renal function in the discovery sample (P<6.5�10?4) and remained significant after validation. Those glycan traits belong to three main glycosylation features: galactosylation, sialylation, and level of bisecting N-acetylglucosamine of the IgG glycans. These results show the role of IgG glycosylation in kidney function and provide novel insight into the pathophysiology of CKD and potential diagnostic and therapeutic targets. Twit Text FOAVip Glycosylation Profile of IgG in Moderate Kidney Dysfunction ????J Am Soc Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=26185202 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26185202 #FOAvip English Wikipedia <ref>{{Cite pmid|26185202}}</ref> Glycosylation Profile of IgG in Moderate Kidney Dysfunction #MMPMID26185202 Barrios C; Zierer J; Gudelj I; ?tambuk J; Ugrina I; Rodr�guez E; Soler MJ; Pavi? T; ?imurina M; Keser T; Pu?i?-Bakovi? M; Mangino M; Pascual J; Spector TD; Lauc G; Menni C J Am Soc Nephrol 2016[Mar]; 27 (3): 933-41 PMID26185202show ga Glycans constitute the most abundant and diverse form of the post-translational modifications, and animal studies have suggested the involvement of IgG glycosylation in mechanisms of renal damage. Here, we explored the associations between IgG glycans and renal function in 3274 individuals from the TwinsUK registry. We analyzed the correlation between renal function measured as eGFR and 76 N-glycan traits using linear regressions adjusted for covariates and multiple testing in the larger population. We replicated our results in 31 monozygotic twin pairs discordant for renal function. Results from both analyses were then meta-analyzed. Fourteen glycan traits were associated with renal function in the discovery sample (P<6.5�10?4) and remained significant after validation. Those glycan traits belong to three main glycosylation features: galactosylation, sialylation, and level of bisecting N-acetylglucosamine of the IgG glycans. These results show the role of IgG glycosylation in kidney function and provide novel insight into the pathophysiology of CKD and potential diagnostic and therapeutic targets. �Glycosylation Profile of IgG in Moderate Kidney Dysfunction (epmc).pdf DeepDyve Pubget Overpricing