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10.1007/s11302-016-9509-4 http://scihub22266oqcxt.onion/10.1007/s11302-016-9509-4 C5023624!5023624!27002712     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27002712.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Purinergic+Signal 2016 ; 12 (3): 411-26 Nephropedia Template TP {{tp|p=27002712|t=2016. Guanosine and its role in neuropathologies |pdf=|usr=}}{{27002712}} gab.com Text Guanosine and its role in neuropathologies JO: Purinergic Signal http://www.kidney.de/pget.php?&tw=1&pmid=27002712 #FOAvip Guanosine is a purine nucleoside thought to have neuroprotective properties. It is released in the brain under physiological conditions and even more during pathological events, reducing neuroinflammation, oxidative stress, and excitotoxicity, as well as exerting trophic effects in neuronal and glial cells. In agreement, guanosine was shown to be protective in several in vitro and/or in vivo experimental models of central nervous system (CNS) diseases including ischemic stroke, Alzheimer?s disease, Parkinson?s disease, spinal cord injury, nociception, and depression. The mechanisms underlying the neurobiological properties of guanosine seem to involve the activation of several intracellular signaling pathways and a close interaction with the adenosinergic system, with a consequent stimulation of neuroprotective and regenerative processes in the CNS. Within this context, the present review will provide an overview of the current literature on the effects of guanosine in the CNS. The elucidation of the complex signaling events underlying the biochemical and cellular effects of this nucleoside may further establish guanosine as a potential therapeutic target for the treatment of several neuropathologies. Twit Text FOAVip Guanosine and its role in neuropathologies ????Purinergic Signal http://www.kidney.de/pget.php?&tw=1&pmid=27002712 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27002712 #FOAvip English Wikipedia <ref>{{Cite pmid|27002712}}</ref> Guanosine and its role in neuropathologies #MMPMID27002712 Bettio LEB; Gil-Mohapel J; Rodrigues ALS Purinergic Signal 2016[Sep]; 12 (3): 411-26 PMID27002712show ga Guanosine is a purine nucleoside thought to have neuroprotective properties. It is released in the brain under physiological conditions and even more during pathological events, reducing neuroinflammation, oxidative stress, and excitotoxicity, as well as exerting trophic effects in neuronal and glial cells. In agreement, guanosine was shown to be protective in several in vitro and/or in vivo experimental models of central nervous system (CNS) diseases including ischemic stroke, Alzheimer?s disease, Parkinson?s disease, spinal cord injury, nociception, and depression. The mechanisms underlying the neurobiological properties of guanosine seem to involve the activation of several intracellular signaling pathways and a close interaction with the adenosinergic system, with a consequent stimulation of neuroprotective and regenerative processes in the CNS. Within this context, the present review will provide an overview of the current literature on the effects of guanosine in the CNS. The elucidation of the complex signaling events underlying the biochemical and cellular effects of this nucleoside may further establish guanosine as a potential therapeutic target for the treatment of several neuropathologies. äGuanosine and its role in neuropathologies (epmc).pdf DeepDyve Pubget Overpricing