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10.1016/j.molcel.2015.03.006 http://scihub22266oqcxt.onion/10.1016/j.molcel.2015.03.006 C4406478!4406478!25866246     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25866246.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Mol+Cell 2015 ; 58 (2): 353-61 Nephropedia Template TP {{tp|p=25866246|t=2015. HOTAIR forms an intricate and modular secondary structure |pdf=|usr=}}{{25866246}} gab.com Text HOTAIR forms an intricate and modular secondary structure JO: Mol Cell http://www.kidney.de/pget.php?&tw=1&pmid=25866246 #FOAvip Long non-coding RNAs (lncRNAs) have recently emerged as key players in fundamental cellular processes and diseases, but their functions are poorly understood. HOTAIR is a 2,148-nucleotide-long lncRNA molecule involved in physiological epidermal development and in pathogenic cancer progression, where it has been demonstrated to repress tumor and metastasis suppressor genes. To gain insights into the molecular mechanisms of HOTAIR, we purified it in a stable and homogenous form in vitro and we determined its functional secondary structure through chemical probing and phylogenetic analysis. The HOTAIR structure reveals a degree of structural organization comparable to well-folded RNAs, like the group II intron, rRNA or lncRNA steroid receptor activator. It is composed of four independently-folding modules, two of which correspond to predicted protein-binding domains. Secondary structure elements that surround protein-binding motifs are evolutionarily conserved. Our work serves as a guide for ?navigating? through the lncRNA HOTAIR and ultimately for understanding its function. Twit Text FOAVip HOTAIR forms an intricate and modular secondary structure ????Mol Cell http://www.kidney.de/pget.php?&tw=1&pmid=25866246 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25866246 #FOAvip English Wikipedia <ref>{{Cite pmid|25866246}}</ref> HOTAIR forms an intricate and modular secondary structure #MMPMID25866246 Somarowthu S; Legiewicz M; Chillón I; Marcia M; Liu F; Pyle AM Mol Cell 2015[Apr]; 58 (2): 353-61 PMID25866246show ga Long non-coding RNAs (lncRNAs) have recently emerged as key players in fundamental cellular processes and diseases, but their functions are poorly understood. HOTAIR is a 2,148-nucleotide-long lncRNA molecule involved in physiological epidermal development and in pathogenic cancer progression, where it has been demonstrated to repress tumor and metastasis suppressor genes. To gain insights into the molecular mechanisms of HOTAIR, we purified it in a stable and homogenous form in vitro and we determined its functional secondary structure through chemical probing and phylogenetic analysis. The HOTAIR structure reveals a degree of structural organization comparable to well-folded RNAs, like the group II intron, rRNA or lncRNA steroid receptor activator. It is composed of four independently-folding modules, two of which correspond to predicted protein-binding domains. Secondary structure elements that surround protein-binding motifs are evolutionarily conserved. Our work serves as a guide for ?navigating? through the lncRNA HOTAIR and ultimately for understanding its function. äHOTAIR forms an intricate and modular secondary structure (epmc).pdf DeepDyve Pubget Overpricing