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10.1016/j.biotechadv.2016.04.005 http://scihub22266oqcxt.onion/10.1016/j.biotechadv.2016.04.005 C4947437!4947437!27143654     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27143654&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27143654.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Biotechnol+Adv 2016 ; 34 (5): 803-12 Nephropedia Template TP {{tp|p=27143654|t=2016. Hypoxic Tumor Microenvironment: Opportunities to Develop Targeted Therapies |pdf=|usr=}}{{27143654}} gab.com Text Hypoxic Tumor Microenvironment: Opportunities to Develop Targeted Therapies JO: Biotechnol Adv http://www.kidney.de/pget.php?&tw=1&pmid=27143654 #FOAvip Recent few years have seen great progress in understanding tumor biology and surrounding microenvironment. Solid tumors create regions with low oxygen levels, generally termed as hypoxic regions. These hypoxic areas offer a tremendous opportunity to develop targeted therapies. Hypoxia is not a random by-product of cellular milieu due to uncontrolled tumor growth; rather it is a constantly evolving participant in overall tumor growth and fate. This article reviews current trends and recent advances in drug therapies and delivery systems targeting hypoxia in the tumor microenvironment. In the first part, we give an account of important physicochemical changes and signaling pathways activated in the hypoxic microenvironment. This is then followed by various treatment strategies including hypoxia-sensitive signaling pathways and approaches to develop hypoxia-targeted drug delivery systems. Twit Text FOAVip Hypoxic Tumor Microenvironment: Opportunities to Develop Targeted Therapies ????Biotechnol Adv http://www.kidney.de/pget.php?&tw=1&pmid=27143654 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27143654 #FOAvip English Wikipedia <ref>{{Cite pmid|27143654}}</ref> Hypoxic Tumor Microenvironment: Opportunities to Develop Targeted Therapies #MMPMID27143654 Patel A; Sant S Biotechnol Adv 2016[Sep]; 34 (5): 803-12 PMID27143654show ga Recent few years have seen great progress in understanding tumor biology and surrounding microenvironment. Solid tumors create regions with low oxygen levels, generally termed as hypoxic regions. These hypoxic areas offer a tremendous opportunity to develop targeted therapies. Hypoxia is not a random by-product of cellular milieu due to uncontrolled tumor growth; rather it is a constantly evolving participant in overall tumor growth and fate. This article reviews current trends and recent advances in drug therapies and delivery systems targeting hypoxia in the tumor microenvironment. In the first part, we give an account of important physicochemical changes and signaling pathways activated in the hypoxic microenvironment. This is then followed by various treatment strategies including hypoxia-sensitive signaling pathways and approaches to develop hypoxia-targeted drug delivery systems. äHypoxic Tumor Microenvironment: Opportunities to Develop Targeted Ther(epmc).pdf DeepDyve Pubget Overpricing