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IPEX Syndrome, FOXP3 and Cancer #MMPMID25844400
Liu R; Li S; Yang WH; Wang L
J Syndr 2013[Jun]; 1 (1): ä PMID25844400show ga
In this review, we introduce the IPEX syndrome and its relationship with germline mutations of the FOXP3 gene. We then describe the multiple functional roles of FOXP3 in regulatory T cells and epithelial cells as well as in IPEX syndrome and tumor progression. Potential mechanisms of FOXP3 inactivation and transcriptional regulation are discussed with recent advances. Finally, we point out current issues and a potential FOXP3-mediated therapeutic strategy as well as the reactivation of FOXP3 in patients with IPEX syndrome and cancer.