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10.5001/omj.2018.20

http://scihub22266oqcxt.onion/10.5001/omj.2018.20
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C5889841!5889841!29657677
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suck abstract from ncbi


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pmid29657677      Oman+Med+J 2018 ; 33 (2): 97-103
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  • Immunoglobulin G4-Related Disease: An Update #MMPMID29657677
  • Al-Mujaini A; Al-Khabori M; Shenoy K; Wali U
  • Oman Med J 2018[Mar]; 33 (2): 97-103 PMID29657677show ga
  • Immunoglobulin G4-related disease (IgG4-RD) is an increasingly recognized immune-mediated condition comprised of a collection of disorders that share specific pathological, serological, and clinical features. IgG4-RD is a fibroinflammatory condition with a tendency to form tumors with inflammatory infiltrate with IgG4 rich plasma cells and elevation of serum IgG4, which may affect virtually every organ and tissue. IgG4-related ophthalmic disease may present as dacryoadenitis, myositis, or involvement of other orbital tissue. Hypophysitis or pachymeningitis may manifest as cranial neuropathies. The diagnosis of IgG4-RD is based on a typical clinical scenario, supportive laboratory test, expected radiological characteristics, and distinct histopathological and immunohistochemical features. Corticosteroids and immunosuppressives form the mainline treatment.
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