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10.1016/B978-0-12-397863-9.00003-1 http://scihub22266oqcxt.onion/10.1016/B978-0-12-397863-9.00003-1 C4405001!4405001!22727420     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=22727420&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\22727420.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Prog+Mol+Biol+Transl+Sci 2012 ; 109 (ä): 75-112 Nephropedia Template TP {{tp|p=22727420|t=2012. Immunoproteasomes: Structure, Function, and Antigen Presentation |pdf=|usr=}}{{22727420}} gab.com Text Immunoproteasomes: Structure, Function, and Antigen Presentation JO: Prog Mol Biol Transl Sci http://www.kidney.de/pget.php?&tw=1&pmid=22727420 #FOAvip Immunoproteasomes contain replacements for the three catalytic subunits of standard proteasomes. In most cells, oxidative stress and proinflammatory cytokines are stimuli that lead to elevated production of immunoproteasomes. Immune system cells, especially antigen-presenting cells, express a higher basal level of immunoproteasomes. A well-described function of immunoprotea-somes is to generate peptides with a hydrophobic C terminus that can be processed to fit in the groove of MHC class I molecules. This display of peptides on the cell surface allows surveillance by CD8 T cells of the adaptive immune system for pathogen-infected cells. Functions of immunoprotea-somes, other than generating peptides for antigen presentation, are emerging from studies in immunoproteasome-deficient mice, and are complemented by recently described diseases linked to mutations or single-nucleotide polymorphisms in immunoproteasome subunits. Thus, this growing body of literature suggests a more pleiotropic role in cell function for the immunoproteasome. Twit Text FOAVip Immunoproteasomes: Structure, Function, and Antigen Presentation ????Prog Mol Biol Transl Sci http://www.kidney.de/pget.php?&tw=1&pmid=22727420 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=22727420 #FOAvip English Wikipedia <ref>{{Cite pmid|22727420}}</ref> Immunoproteasomes: Structure, Function, and Antigen Presentation #MMPMID22727420 Ferrington DA; Gregerson DS Prog Mol Biol Transl Sci 2012[]; 109 (ä): 75-112 PMID22727420show ga Immunoproteasomes contain replacements for the three catalytic subunits of standard proteasomes. In most cells, oxidative stress and proinflammatory cytokines are stimuli that lead to elevated production of immunoproteasomes. Immune system cells, especially antigen-presenting cells, express a higher basal level of immunoproteasomes. A well-described function of immunoprotea-somes is to generate peptides with a hydrophobic C terminus that can be processed to fit in the groove of MHC class I molecules. This display of peptides on the cell surface allows surveillance by CD8 T cells of the adaptive immune system for pathogen-infected cells. Functions of immunoprotea-somes, other than generating peptides for antigen presentation, are emerging from studies in immunoproteasome-deficient mice, and are complemented by recently described diseases linked to mutations or single-nucleotide polymorphisms in immunoproteasome subunits. Thus, this growing body of literature suggests a more pleiotropic role in cell function for the immunoproteasome. äImmunoproteasomes: Structure, Function, and Antigen Presentation (epmc).pdf DeepDyve Pubget Overpricing