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10.1111/imr.12198 http://scihub22266oqcxt.onion/10.1111/imr.12198 C4135451!4135451!25123278     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25123278.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Immunol+Rev 2014 ; 261 (1): 84-101 Nephropedia Template TP {{tp|p=25123278|t=2014. Innate Immune Regulation by STAT-mediated Transcriptional Mechanisms |pdf=|usr=}}{{25123278}} gab.com Text Innate Immune Regulation by STAT-mediated Transcriptional Mechanisms JO: Immunol Rev http://www.kidney.de/pget.php?&tw=1&pmid=25123278 #FOAvip The term innate immunity typically refers to a quick but nonspecific host defense response against invading pathogens. The innate immune system comprises particular immune cell populations, epithelial barriers, and numerous secretory mediators including cytokines, chemokines, and defense peptides. Innate immune cells are also now recognized to play important contributing roles in cancer and pathological inflammatory conditions. Innate immunity relies on rapid signal transduction elicited upon pathogen recognition via pattern recognition receptors (PRRs) and cell:cell communication conducted by soluble mediators, including cytokines. A majority of cytokines involved in innate immune signaling use a molecular cascade encompassing receptor-associated Jak protein tyrosine kinases and STAT (signal transducer and activator of transcription) transcriptional regulators. Here, we focus on roles for STAT proteins in three major innate immune subsets: neutrophils, macrophages, and dendritic cells (DCs). While knowledge in this area is only now emerging, understanding the molecular regulation of these cell types is necessary for developing new approaches to treat human disorders such as inflammatory conditions, autoimmunity, and cancer. Twit Text FOAVip Innate Immune Regulation by STAT-mediated Transcriptional Mechanisms ????Immunol Rev http://www.kidney.de/pget.php?&tw=1&pmid=25123278 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25123278 #FOAvip English Wikipedia <ref>{{Cite pmid|25123278}}</ref> Innate Immune Regulation by STAT-mediated Transcriptional Mechanisms #MMPMID25123278 Li HS; Watowich SS Immunol Rev 2014[Sep]; 261 (1): 84-101 PMID25123278show ga The term innate immunity typically refers to a quick but nonspecific host defense response against invading pathogens. The innate immune system comprises particular immune cell populations, epithelial barriers, and numerous secretory mediators including cytokines, chemokines, and defense peptides. Innate immune cells are also now recognized to play important contributing roles in cancer and pathological inflammatory conditions. Innate immunity relies on rapid signal transduction elicited upon pathogen recognition via pattern recognition receptors (PRRs) and cell:cell communication conducted by soluble mediators, including cytokines. A majority of cytokines involved in innate immune signaling use a molecular cascade encompassing receptor-associated Jak protein tyrosine kinases and STAT (signal transducer and activator of transcription) transcriptional regulators. Here, we focus on roles for STAT proteins in three major innate immune subsets: neutrophils, macrophages, and dendritic cells (DCs). While knowledge in this area is only now emerging, understanding the molecular regulation of these cell types is necessary for developing new approaches to treat human disorders such as inflammatory conditions, autoimmunity, and cancer. äInnate Immune Regulation by STAT-mediated Transcriptional Mechanisms (epmc).pdf DeepDyve Pubget Overpricing