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10.1158/1940-6207.CAPR-15-0343 http://scihub22266oqcxt.onion/10.1158/1940-6207.CAPR-15-0343 C4856031!4856031!26932841     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26932841&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26932841.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cancer+Prev+Res+(Phila) 2016 ; 9 (5): 335-8 Nephropedia Template TP {{tp|p=26932841|t=2016. Commentary: Limitations of the driver/passenger model in cancer prevention |pdf=|usr=}}{{26932841}} gab.com Text Commentary: Limitations of the driver/passenger model in cancer prevention JO: Cancer Prev Res (Phila) http://www.kidney.de/pget.php?&tw=1&pmid=26932841 #FOAvip Mutations detected in cancers are often divided into ?drivers? and ?passengers.? We suggest that this classification is potentially misleading for purposes of early detection and prevention. Specifically, some mutations are frequent in tumors and thus appear to be drivers, but are poor predictors of cancer; other mutations are individually rare and thus appear to be passengers, but may collectively explain a large proportion of risk. The assumptions bundled into the terms ?driver? and ?passenger? can lead to misunderstandings of neoplastic progression, with unintended consequences including overdiagnosis, overtreatment, and failure to identify the true sources of risk. We argue that samples from healthy, benign, or neoplastic tissues are critical for evaluating the risk of future cancer posed by mutations in a given gene. Twit Text FOAVip Commentary: Limitations of the driver/passenger model in cancer prevention ????Cancer Prev Res (Phila) http://www.kidney.de/pget.php?&tw=1&pmid=26932841 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26932841 #FOAvip English Wikipedia <ref>{{Cite pmid|26932841}}</ref> Commentary: Limitations of the driver/passenger model in cancer prevention #MMPMID26932841 Kuhner MK; Kostadinov R; Reid BJ Cancer Prev Res (Phila) 2016[May]; 9 (5): 335-8 PMID26932841show ga Mutations detected in cancers are often divided into ?drivers? and ?passengers.? We suggest that this classification is potentially misleading for purposes of early detection and prevention. Specifically, some mutations are frequent in tumors and thus appear to be drivers, but are poor predictors of cancer; other mutations are individually rare and thus appear to be passengers, but may collectively explain a large proportion of risk. The assumptions bundled into the terms ?driver? and ?passenger? can lead to misunderstandings of neoplastic progression, with unintended consequences including overdiagnosis, overtreatment, and failure to identify the true sources of risk. We argue that samples from healthy, benign, or neoplastic tissues are critical for evaluating the risk of future cancer posed by mutations in a given gene. äCommentary: Limitations of the driver/passenger model in cancer preven(epmc).pdf DeepDyve Pubget Overpricing