Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28924382.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Int+J+Biol+Sci 2017 ; 13 (8): 1008-18 Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Linker Histone in Diseases #MMPMID28924382
Ye X; Feng C; Gao T; Mu G; Zhu W; Yang Y
Int J Biol Sci 2017[]; 13 (8): 1008-18 PMID28924382show ga
The linker histone is a protein that binds with the nucleosome, which is generally considered to achieve chromatin condensation in the nucleus. Accumulating evidences suggest that the linker histone is essential in the pathogenesis of several diseases. In this review, we briefly introduce the current knowledge of the linker histone, including its structure, characteristics and functions. Also, we move forward to present the advances of the linker histone's association with certain diseases, such as cancer, Alzheimer's disease, infection, male infertility and aberrant immunity situations, focusing on the alteration of the linker histone under certain pathological conditions and its role in developing each disease.