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Lipid Droplet Biogenesis and Function in the Endothelium #MMPMID28119423
Kuo A; Lee MY; Sessa WC
Circ Res 2017[Apr]; 120 (8): 1289-97 PMID28119423show ga
Rationale: Fatty acids (FA) are transported across the capillary endothelium to parenchymal tissues. However, it is not known how endothelial cells (EC) process a post-prandial surge of FA. Objective: This study was designed to characterize lipid droplet (LD) formation and function in EC. Methods and Results: LD form and degrade in EC in vivo after FA loading. In cultured EC, LD synthesis and turnover is dynamic and function to protect EC from lipotoxic stress and provide FA for metabolic needs. Conclusions: Our results delineate endothelial LD dynamics for the first time, demonstrating their protective role in lipotoxicity, FA utilization and mobilization.