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10.1016/j.coviro.2015.01.011 http://scihub22266oqcxt.onion/10.1016/j.coviro.2015.01.011 C4470736!4470736!25676875     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25676875.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Curr+Opin+Virol 2015 ; 12 (ä): 20-5 Nephropedia Template TP {{tp|p=25676875|t=2015. MDA5 - filament, dynamics and disease |pdf=|usr=}}{{25676875}} gab.com Text MDA5 - filament, dynamics and disease JO: Curr Opin Virol http://www.kidney.de/pget.php?&tw=1&pmid=25676875 #FOAvip Melanoma Differentiation-Associated gene 5 (MDA5), encoded by the gene IFIH1, is a cytoplasmic sensor for viral double-stranded RNAs (dsRNAs). MDA5 activates the type I interferon signaling pathway upon detection of long viral dsRNA generated during replication of picornaviruses. Studies have shown that MDA5 forms a filament along the length of dsRNA and utilizes ATP-dependent filament dynamics to discriminate between self vs non-self on the basis of dsRNA length. This review summarizes our current understanding of how the MDA5 filament assembles and disassembles, how this filament dynamics are utilized in dsRNA length-dependent signaling, and how dysregulated filament dynamics lead to pathogenesis of immune disorders. Twit Text FOAVip MDA5 - filament, dynamics and disease ????Curr Opin Virol http://www.kidney.de/pget.php?&tw=1&pmid=25676875 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25676875 #FOAvip English Wikipedia <ref>{{Cite pmid|25676875}}</ref> MDA5 - filament, dynamics and disease #MMPMID25676875 Duany Ydel T; Wu B; Hur S Curr Opin Virol 2015[Jun]; 12 (ä): 20-5 PMID25676875show ga Melanoma Differentiation-Associated gene 5 (MDA5), encoded by the gene IFIH1, is a cytoplasmic sensor for viral double-stranded RNAs (dsRNAs). MDA5 activates the type I interferon signaling pathway upon detection of long viral dsRNA generated during replication of picornaviruses. Studies have shown that MDA5 forms a filament along the length of dsRNA and utilizes ATP-dependent filament dynamics to discriminate between self vs non-self on the basis of dsRNA length. This review summarizes our current understanding of how the MDA5 filament assembles and disassembles, how this filament dynamics are utilized in dsRNA length-dependent signaling, and how dysregulated filament dynamics lead to pathogenesis of immune disorders. äMDA5 - filament, dynamics and disease (epmc).pdf DeepDyve Pubget Overpricing