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Mechanical communication at the immunological synapse #MMPMID27986534
Basu R; Huse M
Trends Cell Biol 2017[Apr]; 27 (4): 241-54 PMID27986534show ga
T and B lymphocytes communicate by forming immunological synapses with antigen-presenting target cells. These highly dynamic contacts are characterized by continuous cytoskeletal remodeling events, which not only structure the interface but also exert a considerable amount of mechanical force. In recent years, it has become increasingly clear that synaptic forces influence information transfer both into and out of the lymphocyte. Here, we review our current understanding of synapse mechanics, focusing on its role as an avenue for intercellular communication.