
| 10.3109/10409238.2016.1172555
http://scihub22266oqcxt.onion/10.3109/10409238.2016.1172555
 C4915340!4915340!27098510
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Crit+Rev+Biochem+Mol+Biol 2016 ; 51 (4): 282-93 Nephropedia Template TP
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Metabolic regulation via enzyme filamentation #MMPMID27098510Aughey GN; Liu JLCrit Rev Biochem Mol Biol 2016[Jul]; 51 (4): 282-93 PMID27098510show ga
Determining the mechanisms of enzymatic regulation is central to the study of cellular metabolism. Regulation of enzyme activity via polymerization-mediated strategies has been shown to be widespread, and plays a vital role in mediating cellular homeostasis. In this review, we begin with an overview of the filamentation of CTP synthase, which forms filamentous structures termed cytoophidia. We then highlight other important examples of the phenomenon. Moreover, we discuss recent data relating to the regulation of enzyme activity by compartmentalization into cytoophidia. Finally, we hypothesize potential roles for enzyme filament formation in the regulation of metabolism, development and disease.�
  
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