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10.4161/23723548.2014.963445

http://scihub22266oqcxt.onion/10.4161/23723548.2014.963445
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C4655600!4655600!26609545
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suck abstract from ncbi


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pmid26609545      Mol+Cell+Oncol 2014 ; 1 (3): ä
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  • Metabolic vulnerability of KRAS-driven cancer cells #MMPMID26609545
  • Foster DA
  • Mol Cell Oncol 2014[Jul]; 1 (3): ä PMID26609545show ga
  • Interfering with anaplerotic utilization of glutamine (Gln) was recently reported to sensitize KRAS-driven cancer cells to the cytotoxic effects of capecitabine and paclitaxel. This effect was due to bypass of a Gln-dependent G1 cell cycle checkpoint in these cells. This study highlights therapeutic opportunities created by metabolic reprogramming in cancer cells.
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