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10.1371/journal.pone.0151179 http://scihub22266oqcxt.onion/10.1371/journal.pone.0151179 C4784930!4784930!26959405     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26959405.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       PLoS+One 2016 ; 11 (3): ä Nephropedia Template TP {{tp|p=26959405|t=2016. Metformin Decouples Phospholipid Metabolism in Breast Cancer Cells |pdf=|usr=}}{{26959405}} gab.com Text Metformin Decouples Phospholipid Metabolism in Breast Cancer Cells JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=26959405 #FOAvip Introduction: The antidiabetic drug metformin, currently undergoing trials for cancer treatment, modulates lipid and glucose metabolism both crucial in phospholipid synthesis. Here the effect of treatment of breast tumour cells with metformin on phosphatidylcholine (PtdCho) metabolism which plays a key role in membrane synthesis and intracellular signalling has been examined. Methods: MDA-MB-468, BT474 and SKBr3 breast cancer cell lines were treated with metformin and [3H-methyl]choline and [14C(U)]glucose incorporation and lipid accumulation determined in the presence and absence of lipase inhibitors. Activities of choline kinase (CK), CTP:phosphocholine cytidylyl transferase (CCT) and PtdCho-phospholipase C (PLC) were also measured. [3H] Radiolabelled metabolites were determined using thin layer chromatography. Results: Metformin-treated cells exhibited decreased formation of [3H]phosphocholine but increased accumulation of [3H]choline by PtdCho. CK and PLC activities were decreased and CCT activity increased by metformin-treatment. [14C] incorporation into fatty acids was decreased and into glycerol was increased in breast cancer cells treated with metformin incubated with [14C(U)]glucose. Conclusion: This is the first study to show that treatment of breast cancer cells with metformin induces profound changes in phospholipid metabolism. Twit Text FOAVip Metformin Decouples Phospholipid Metabolism in Breast Cancer Cells ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=26959405 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26959405 #FOAvip English Wikipedia <ref>{{Cite pmid|26959405}}</ref> Metformin Decouples Phospholipid Metabolism in Breast Cancer Cells #MMPMID26959405 Smith TAD; Phyu SM PLoS One 2016[]; 11 (3): ä PMID26959405show ga Introduction: The antidiabetic drug metformin, currently undergoing trials for cancer treatment, modulates lipid and glucose metabolism both crucial in phospholipid synthesis. Here the effect of treatment of breast tumour cells with metformin on phosphatidylcholine (PtdCho) metabolism which plays a key role in membrane synthesis and intracellular signalling has been examined. Methods: MDA-MB-468, BT474 and SKBr3 breast cancer cell lines were treated with metformin and [3H-methyl]choline and [14C(U)]glucose incorporation and lipid accumulation determined in the presence and absence of lipase inhibitors. Activities of choline kinase (CK), CTP:phosphocholine cytidylyl transferase (CCT) and PtdCho-phospholipase C (PLC) were also measured. [3H] Radiolabelled metabolites were determined using thin layer chromatography. Results: Metformin-treated cells exhibited decreased formation of [3H]phosphocholine but increased accumulation of [3H]choline by PtdCho. CK and PLC activities were decreased and CCT activity increased by metformin-treatment. [14C] incorporation into fatty acids was decreased and into glycerol was increased in breast cancer cells treated with metformin incubated with [14C(U)]glucose. Conclusion: This is the first study to show that treatment of breast cancer cells with metformin induces profound changes in phospholipid metabolism. äMetformin Decouples Phospholipid Metabolism in Breast Cancer Cells (epmc).pdf DeepDyve Pubget Overpricing