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10.4137/BMI.S27676

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C4620936!4620936!26523117
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suck abstract from ncbi


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pmid26523117      Biomark+Insights 2015 ; 10 (ä): 95-102
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  • MicroRNA-155 and Its Role in Malignant Hematopoiesis #MMPMID26523117
  • Ranganath P
  • Biomark Insights 2015[]; 10 (ä): 95-102 PMID26523117show ga
  • MicroRNA-155 (miR-155) is a multifunctional molecule involved in both normal and malignant hematopoiesis. It has been found to be involved in the pathogenesis of many different hematological malignancies with either an oncogenic or a tumor-repressor effect, depending on the nature of the cell and the type of malignancy. In particular, it has been strongly implicated in the causation of diffuse large B-cell lymphomas. This review focuses on the molecular interactions of miR-155, its oncogenic mechanisms, and its potential as an effective therapeutic target for the associated malignancies.
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