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Microtubules in neurons as information carriers #MMPMID24266899
Dent EW; Baas PW
J Neurochem 2014[Apr]; 129 (2): 235-9 PMID24266899show ga
Microtubules in neurons consist of highly dynamic regions as well as stable regions, some of which persist after bouts of severing as short mobile polymers. Concentrated at the plus ends of the highly dynamic regions are proteins called +TIPs that can interact with an array of other proteins and structures relevant to the plasticity of the neuron. It is also provocative to ponder that short mobile microtubules might similarly convey information with them as they transit within the neuron. Thus beyond their known conventional functions in supporting neuronal architecture and organelle transport, microtubules may act as ?information carriers? in the neuron.Microtubules are major architectural elements without which the neuron could not achieve or maintain its exaggerated shape. In addition to serving as structural elements, microtubules are railways along which molecular motor proteins convey cargo. Microtubule arrays in axons, dendrites, growth cones, and migratory neurons are tightly organized with respect to the intrinsic polarity of the microtubule, which is relevant to both its assembly and transport properties. Vibrant research is being conducted on the mechanisms by which microtubules are organized in different compartments of the neuron, how microtubule dynamics and stability are regulated, and the orchestration of microtubule-based transport of organelles and proteins. While all of this is surely enough to cause one to marvel, we cannot avoid pondering - what other work might microtubules do for neurons?
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J+Neurochem 2014 ; 129 (2): 235-9
