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10.1186/s13008-016-0015-4 http://scihub22266oqcxt.onion/10.1186/s13008-016-0015-4 C4812650!4812650!27030796     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27030796.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cell+Div 2016 ; 11 (ä): ä Nephropedia Template TP {{tp|p=27030796|t=2016. Mitochondria-cytoskeleton associations in mammalian cytokinesis |pdf=|usr=}}{{27030796}} gab.com Text Mitochondria-cytoskeleton associations in mammalian cytokinesis JO: Cell Div http://www.kidney.de/pget.php?&tw=1&pmid=27030796 #FOAvip Background: The role of the cytoskeleton in regulating mitochondrial distribution in dividing mammalian cells is poorly understood. We previously demonstrated that mitochondria are transported to the cleavage furrow during cytokinesis in a microtubule-dependent manner. However, the exact subset of spindle microtubules and molecular machinery involved remains unknown. Methods: We employed quantitative imaging techniques and structured illumination microscopy to analyse the spatial and temporal relationship of mitochondria with microtubules and actin of the contractile ring during cytokinesis in HeLa cells. Results: Superresolution microscopy revealed that mitochondria were associated with astral microtubules of the mitotic spindle in cytokinetic cells. Dominant-negative mutants of KIF5B, the heavy chain of kinesin-1 motor, and of Miro-1 disrupted mitochondrial transport to the furrow. Live imaging revealed that mitochondrial enrichment at the cell equator occurred simultaneously with the appearance of the contractile ring in cytokinesis. Inhibiting RhoA activity and contractile ring assembly with C3 transferase, caused mitochondrial mislocalisation during division. Conclusions: Taken together, the data suggest a model in which mitochondria are transported by a microtubule-mediated mechanism involving equatorial astral microtubules, Miro-1, and KIF5B to the nascent actomyosin contractile ring in cytokinesis. Electronic supplementary material: The online version of this article (doi:10.1186/s13008-016-0015-4) contains supplementary material, which is available to authorized users. Twit Text FOAVip Mitochondria-cytoskeleton associations in mammalian cytokinesis ????Cell Div http://www.kidney.de/pget.php?&tw=1&pmid=27030796 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27030796 #FOAvip English Wikipedia <ref>{{Cite pmid|27030796}}</ref> Mitochondria-cytoskeleton associations in mammalian cytokinesis #MMPMID27030796 Lawrence EJ; Boucher E; Mandato CA Cell Div 2016[]; 11 (ä): ä PMID27030796show ga Background: The role of the cytoskeleton in regulating mitochondrial distribution in dividing mammalian cells is poorly understood. We previously demonstrated that mitochondria are transported to the cleavage furrow during cytokinesis in a microtubule-dependent manner. However, the exact subset of spindle microtubules and molecular machinery involved remains unknown. Methods: We employed quantitative imaging techniques and structured illumination microscopy to analyse the spatial and temporal relationship of mitochondria with microtubules and actin of the contractile ring during cytokinesis in HeLa cells. Results: Superresolution microscopy revealed that mitochondria were associated with astral microtubules of the mitotic spindle in cytokinetic cells. Dominant-negative mutants of KIF5B, the heavy chain of kinesin-1 motor, and of Miro-1 disrupted mitochondrial transport to the furrow. Live imaging revealed that mitochondrial enrichment at the cell equator occurred simultaneously with the appearance of the contractile ring in cytokinesis. Inhibiting RhoA activity and contractile ring assembly with C3 transferase, caused mitochondrial mislocalisation during division. Conclusions: Taken together, the data suggest a model in which mitochondria are transported by a microtubule-mediated mechanism involving equatorial astral microtubules, Miro-1, and KIF5B to the nascent actomyosin contractile ring in cytokinesis. Electronic supplementary material: The online version of this article (doi:10.1186/s13008-016-0015-4) contains supplementary material, which is available to authorized users. äMitochondria-cytoskeleton associations in mammalian cytokinesis (epmc).pdf DeepDyve Pubget Overpricing