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10.1080/23723556.2016.1179381

http://scihub22266oqcxt.onion/10.1080/23723556.2016.1179381
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C4972122!4972122!27652325
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suck abstract from ncbi


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pmid27652325      Mol+Cell+Oncol 2016 ; 3 (4): ä
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  • Mitochondrial biogenesis meets chemoresistance in BRAF-mutant melanoma #MMPMID27652325
  • Wu LW; Zhang G; Herlyn M
  • Mol Cell Oncol 2016[Jul]; 3 (4): ä PMID27652325show ga
  • The acquisition of resistance to current mitogen activated protein kinase (MAPK) inhibitors in B-Raf proto-oncogene, serine/threonine kinase (BRAF) mutant melanoma is almost inevitable. Our recent findings identify therapy-induced mitochondrial biogenesis (MitoBiogenesis) and aberrant tumor bioenergetics as therapeutic escape mechanisms and offer a rational combinatorial strategy to further improve the efficacy of MAPK inhibitors.
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