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10.1039/C4QO00088A

http://scihub22266oqcxt.onion/10.1039/C4QO00088A
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C4136525!4136525!25147729
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suck abstract from ncbi


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pmid25147729      Org+Chem+Front 2014 ; 1 (7): 834-7
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  • Modern Multicomponent Reactions for better Drug Syntheses** #MMPMID25147729
  • Zarganes-Tzitzikas T; Dömling A
  • Org Chem Front 2014[Sep]; 1 (7): 834-7 PMID25147729show ga
  • Multicomponent reaction (MCR) technology is now widely recognized for its impact on drug discovery projects and is strongly endorsed by industry as well as academia. However, still relatively few products based on MCRs are marketed or under development. This provides tremendous opportunities for organic chemists to shorten synthetic pathways thus reducing the cost-of-goods considerably. A recent example of the HCV drug Telaprevir is highlighted where introduction of two MCRs could lead to a shortening of the synthesis route by more than 50%.
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