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10.5173/ceju.2018.1583 http://scihub22266oqcxt.onion/10.5173/ceju.2018.1583 C6051361!6051361!30038806     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\30038806.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cent+European+J+Urol 2018 ; 71 (2): 168-76 Nephropedia Template TP {{tp|p=30038806|t=2018. Molecular alterations associated with prostate cancer |pdf=|usr=}}{{30038806}} gab.com Text Molecular alterations associated with prostate cancer JO: Cent European J Urol http://www.kidney.de/pget.php?&tw=1&pmid=30038806 #FOAvip Introduction: The amount of information and knowledge about pathways and genetic alterations regarding prostate cancer, including the tools available for its study has been recently increasing. Additionally, a variety of molecular signaling pathways control cell proliferation, however, this incompletely understood process is disturbed in cancer cells. Materials and methods: A literature review was made using the MEDLINE, Embase and LILACS databases searching for the following keywords: prostate neoplasms, prostate cancer, molecular medicine, genomics, pathways, and cell cycle. Results: Different biological mechanisms have been associated with the development of prostate cancer, such as alterations in tumor suppressor genes, oncogenes (TP53, RB1, among others) and CDKIs; DNA methylation; chromosomal alterations and rearrangements; changes in PTEN and PI3K / mTOR; global defects in apoptosis; alterations in the androgen receptor (AR); and epigenetic mechanisms. Conclusions: Good clinical practice and a practical approach have to be based on basic knowledge, thus, in this article, the main genetic alterations, mutations and pathways involved in prostate cancer development were reviewed. Twit Text FOAVip Molecular alterations associated with prostate cancer ????Cent European J Urol http://www.kidney.de/pget.php?&tw=1&pmid=30038806 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=30038806 #FOAvip English Wikipedia <ref>{{Cite pmid|30038806}}</ref> Molecular alterations associated with prostate cancer #MMPMID30038806 Garcia Perdomo HA; Zapata-Copete JA; Sanchez A Cent European J Urol 2018[]; 71 (2): 168-76 PMID30038806show ga Introduction: The amount of information and knowledge about pathways and genetic alterations regarding prostate cancer, including the tools available for its study has been recently increasing. Additionally, a variety of molecular signaling pathways control cell proliferation, however, this incompletely understood process is disturbed in cancer cells. Materials and methods: A literature review was made using the MEDLINE, Embase and LILACS databases searching for the following keywords: prostate neoplasms, prostate cancer, molecular medicine, genomics, pathways, and cell cycle. Results: Different biological mechanisms have been associated with the development of prostate cancer, such as alterations in tumor suppressor genes, oncogenes (TP53, RB1, among others) and CDKIs; DNA methylation; chromosomal alterations and rearrangements; changes in PTEN and PI3K / mTOR; global defects in apoptosis; alterations in the androgen receptor (AR); and epigenetic mechanisms. Conclusions: Good clinical practice and a practical approach have to be based on basic knowledge, thus, in this article, the main genetic alterations, mutations and pathways involved in prostate cancer development were reviewed. äMolecular alterations associated with prostate cancer (epmc).pdf DeepDyve Pubget Overpricing