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10.1152/ajpcell.00007.2016 http://scihub22266oqcxt.onion/10.1152/ajpcell.00007.2016 C4835918!4835918!26825122     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26825122.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Am+J+Physiol+Cell+Physiol 2016 ; 310 (8): C643-62 Nephropedia Template TP {{tp|p=26825122|t=2016. Molecular mechanisms of STIM/Orai communication |pdf=|usr=}}{{26825122}} gab.com Text Molecular mechanisms of STIM/Orai communication JO: Am J Physiol Cell Physiol http://www.kidney.de/pget.php?&tw=1&pmid=26825122 #FOAvip Ca2+ entry into the cell via store-operated Ca2+ release-activated Ca2+ (CRAC) channels triggers diverse signaling cascades that affect cellular processes like cell growth, gene regulation, secretion, and cell death. These store-operated Ca2+ channels open after depletion of intracellular Ca2+ stores, and their main features are fully reconstituted by the two molecular key players: the stromal interaction molecule (STIM) and Orai. STIM represents an endoplasmic reticulum-located Ca2+ sensor, while Orai forms a highly Ca2+-selective ion channel in the plasma membrane. Functional as well as mutagenesis studies together with structural insights about STIM and Orai proteins provide a molecular picture of the interplay of these two key players in the CRAC signaling cascade. This review focuses on the main experimental advances in the understanding of the STIM1-Orai choreography, thereby establishing a portrait of key mechanistic steps in the CRAC channel signaling cascade. The focus is on the activation of the STIM proteins, the subsequent coupling of STIM1 to Orai1, and the consequent structural rearrangements that gate the Orai channels into the open state to allow Ca2+ permeation into the cell. Twit Text FOAVip Molecular mechanisms of STIM/Orai communication ????Am J Physiol Cell Physiol http://www.kidney.de/pget.php?&tw=1&pmid=26825122 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26825122 #FOAvip English Wikipedia <ref>{{Cite pmid|26825122}}</ref> Molecular mechanisms of STIM/Orai communication #MMPMID26825122 Derler I; Jardin I; Romanin C Am J Physiol Cell Physiol 2016[Apr]; 310 (8): C643-62 PMID26825122show ga Ca2+ entry into the cell via store-operated Ca2+ release-activated Ca2+ (CRAC) channels triggers diverse signaling cascades that affect cellular processes like cell growth, gene regulation, secretion, and cell death. These store-operated Ca2+ channels open after depletion of intracellular Ca2+ stores, and their main features are fully reconstituted by the two molecular key players: the stromal interaction molecule (STIM) and Orai. STIM represents an endoplasmic reticulum-located Ca2+ sensor, while Orai forms a highly Ca2+-selective ion channel in the plasma membrane. Functional as well as mutagenesis studies together with structural insights about STIM and Orai proteins provide a molecular picture of the interplay of these two key players in the CRAC signaling cascade. This review focuses on the main experimental advances in the understanding of the STIM1-Orai choreography, thereby establishing a portrait of key mechanistic steps in the CRAC channel signaling cascade. The focus is on the activation of the STIM proteins, the subsequent coupling of STIM1 to Orai1, and the consequent structural rearrangements that gate the Orai channels into the open state to allow Ca2+ permeation into the cell. äMolecular mechanisms of STIM/Orai communication (epmc).pdf DeepDyve Pubget Overpricing