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10.2174/1570159X13666150205143555 http://scihub22266oqcxt.onion/10.2174/1570159X13666150205143555 C4812800!4812800!26411966     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26411966.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Curr+Neuropharmacol 2015 ; 13 (3): 389-94 Nephropedia Template TP {{tp|p=26411966|t=2015. Neuropharmacological Actions of Metformin in Stroke |pdf=|usr=}}{{26411966}} gab.com Text Neuropharmacological Actions of Metformin in Stroke JO: Curr Neuropharmacol http://www.kidney.de/pget.php?&tw=1&pmid=26411966 #FOAvip Increasing epidemiologic evidence suggests that metformin, a well-established AMPK activator and the most favorable first-line anti-diabetic drug, reduces stroke incidence and severity. However, the mechanism for this remains unclear. Moreover, previous experimental studies have reported controversial results about the effects of metformin on stroke outcomes during the acute phase. However, recent studies have consistently suggested that AMPK-mediated microglia/macrophage polarization and angioneurogenesis may play essential roles in metformin-promoted, long-term functional recovery following stroke. The present review summarizes the neuropharmacological actions of metformin in experimental stroke with an emphasis on the recent findings that the cell-specific effects and duration of AMPK activation are critical to the effects of metformin on stroke outcomes. Twit Text FOAVip Neuropharmacological Actions of Metformin in Stroke ????Curr Neuropharmacol http://www.kidney.de/pget.php?&tw=1&pmid=26411966 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26411966 #FOAvip English Wikipedia <ref>{{Cite pmid|26411966}}</ref> Neuropharmacological Actions of Metformin in Stroke #MMPMID26411966 Jia J; Cheng J; Ni J; Zhen X Curr Neuropharmacol 2015[May]; 13 (3): 389-94 PMID26411966show ga Increasing epidemiologic evidence suggests that metformin, a well-established AMPK activator and the most favorable first-line anti-diabetic drug, reduces stroke incidence and severity. However, the mechanism for this remains unclear. Moreover, previous experimental studies have reported controversial results about the effects of metformin on stroke outcomes during the acute phase. However, recent studies have consistently suggested that AMPK-mediated microglia/macrophage polarization and angioneurogenesis may play essential roles in metformin-promoted, long-term functional recovery following stroke. The present review summarizes the neuropharmacological actions of metformin in experimental stroke with an emphasis on the recent findings that the cell-specific effects and duration of AMPK activation are critical to the effects of metformin on stroke outcomes. äNeuropharmacological Actions of Metformin in Stroke (epmc).pdf DeepDyve Pubget Overpricing