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Notch signaling as a novel regulator of metabolism #MMPMID25805408
Bi P; Kuang S
Trends Endocrinol Metab 2015[May]; 26 (5): 248-55 PMID25805408show ga
Evolutionarily unprepared for modern high caloric diets and sedentary lifestyles, humans are now unprecedentedly susceptible to metabolic disorders such as obesity, type 2 diabetes, nonalcoholic fatty liver, and cardiovascular diseases. These metabolic conditions are intertwined, together known as metabolic syndrome, to compromise human life quality as well as lives. Notch signaling, a fundamental signal transduction pathway critical for cell-cell communication and development has recently been recognized as a key player in metabolism. This review summarizes the emerging roles of Notch signaling in regulating metabolism of various cell or tissue types, with emphasis on the underlying molecular mechanisms and potentials of targeting this signal axis to treat metabolic diseases.