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10.1097/MOT.0b013e328342551c

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C4855507!4855507!21150607
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suck abstract from ncbi


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pmid21150607      Curr+Opin+Organ+Transplant 2011 ; 16 (1): 61-8
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  • Novel functions of B cells in Transplantation #MMPMID21150607
  • Platt JL; Tsuji S; Cascalho M
  • Curr Opin Organ Transplant 2011[Feb]; 16 (1): 61-8 PMID21150607show ga
  • Purpose of review: This manuscript will review current knowledge and recent findings regarding antibody-independent functions of B cells in transplantation. Recent findings: Until recently the functions of B cells in transplantation have been attributed almost entirely to the antibodies they produce. However, the results of recent trials of B cell depleting agents for treatment of antibody mediated rejection as well as auto-immune disease raised awareness that B cells mediate functions independent of antibody synthesis. Summary: These ?non-classical? functions place B cells at the center of immune regulation with the power to enhance or inhibit immunity.
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