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10.1371/journal.ppat.1006950 http://scihub22266oqcxt.onion/10.1371/journal.ppat.1006950 C5875879!5875879!29554134     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29554134.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       PLoS+Pathog 2018 ; 14 (3): ä Nephropedia Template TP {{tp|p=29554134|t=2018. Nuclear RNA surveillance complexes silence HIV-1 transcription |pdf=|usr=}}{{29554134}} gab.com Text Nuclear RNA surveillance complexes silence HIV-1 transcription JO: PLoS Pathog http://www.kidney.de/pget.php?&tw=1&pmid=29554134 #FOAvip Expression from the HIV-1 LTR can be repressed in a small population of cells, which contributes to the latent reservoir. The factors mediating this repression have not been clearly elucidated. We have identified a network of nuclear RNA surveillance factors that act as effectors of HIV-1 silencing. RRP6, MTR4, ZCCHC8 and ZFC3H1 physically associate with the HIV-1 TAR region and repress transcriptional output and recruitment of RNAPII to the LTR. Knock-down of these factors in J-Lat cells increased the number of GFP-positive cells, with a concomitant increase in histone marks associated with transcriptional activation. Loss of these factors increased HIV-1 expression from infected PBMCs and led to reactivation of HIV-1 from latently infected PBMCs. These findings identify a network of novel transcriptional repressors that control HIV-1 expression and which could open new avenues for therapeutic intervention. Twit Text FOAVip Nuclear RNA surveillance complexes silence HIV-1 transcription ????PLoS Pathog http://www.kidney.de/pget.php?&tw=1&pmid=29554134 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29554134 #FOAvip English Wikipedia <ref>{{Cite pmid|29554134}}</ref> Nuclear RNA surveillance complexes silence HIV-1 transcription #MMPMID29554134 Contreras X; Salifou K; Sanchez G; Helsmoortel M; Beyne E; Bluy L; Pelletier S; Rousset E; Rouquier S; Kiernan R PLoS Pathog 2018[Mar]; 14 (3): ä PMID29554134show ga Expression from the HIV-1 LTR can be repressed in a small population of cells, which contributes to the latent reservoir. The factors mediating this repression have not been clearly elucidated. We have identified a network of nuclear RNA surveillance factors that act as effectors of HIV-1 silencing. RRP6, MTR4, ZCCHC8 and ZFC3H1 physically associate with the HIV-1 TAR region and repress transcriptional output and recruitment of RNAPII to the LTR. Knock-down of these factors in J-Lat cells increased the number of GFP-positive cells, with a concomitant increase in histone marks associated with transcriptional activation. Loss of these factors increased HIV-1 expression from infected PBMCs and led to reactivation of HIV-1 from latently infected PBMCs. These findings identify a network of novel transcriptional repressors that control HIV-1 expression and which could open new avenues for therapeutic intervention. äNuclear RNA surveillance complexes silence HIV-1 transcription (epmc).pdf DeepDyve Pubget Overpricing