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10.1007/s11906-016-0658-1

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suck abstract from ncbi


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pmid27262997      Curr+Hypertens+Rep 2016 ; 18 (7): 58
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  • Obesity-Induced Hypertension: Brain Signaling Pathways #MMPMID27262997
  • do Carmo JM; da Silva AA; Wang Z; Fang T; Aberdein N; de Lara Rodriguez CEP; Hall JE
  • Curr Hypertens Rep 2016[Jul]; 18 (7): 58 PMID27262997show ga
  • Obesity greatly increases the risk for cardiovascular, metabolic, and renal diseases and is one of the most significant and preventable causes of increased blood pressure (BP) in patients with essential hypertension. This review high-lights recent advances in our understanding of central nervous system (CNS) signaling pathways that contribute to the etiology and pathogenesis of obesity-induced hypertension. We discuss the role of excess adiposity and activation of the brain leptin-melanocortin system in causing increased sympathetic activity in obesity. In addition, we highlight other potential brain mechanisms by which increased weight gain modulates metabolic and cardiovascular functions. Unraveling the CNS mechanisms responsible for increased sympathetic activation and hypertension and how circulating hormones activate brain signaling pathways to control BP offer potentially important therapeutic targets for obesity and hypertension.
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