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10.1371/journal.pone.0139617 http://scihub22266oqcxt.onion/10.1371/journal.pone.0139617 C4592144!4592144!26431435     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26431435.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       PLoS+One 2015 ; 10 (10): ä Nephropedia Template TP {{tp|p=26431435|t=2015. On the Computing Potential of Intracellular Vesicles |pdf=|usr=}}{{26431435}} gab.com Text On the Computing Potential of Intracellular Vesicles JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=26431435 #FOAvip Collision-based computing (CBC) is a form of unconventional computing in which travelling localisations represent data and conditional routing of signals determines the output state; collisions between localisations represent logical operations. We investigated patterns of Ca2+-containing vesicle distribution within a live organism, slime mould Physarum polycephalum, with confocal microscopy and observed them colliding regularly. Vesicles travel down cytoskeletal ?circuitry? and their collisions may result in reflection, fusion or annihilation. We demonstrate through experimental observations that naturally-occurring vesicle dynamics may be characterised as a computationally-universal set of Boolean logical operations and present a ?vesicle modification? of the archetypal CBC ?billiard ball model? of computation. We proceed to discuss the viability of intracellular vesicles as an unconventional computing substrate in which we delineate practical considerations for reliable vesicle ?programming? in both in vivo and in vitro vesicle computing architectures and present optimised designs for both single logical gates and combinatorial logic circuits based on cytoskeletal network conformations. The results presented here demonstrate the first characterisation of intracelluar phenomena as collision-based computing and hence the viability of biological substrates for computing. Twit Text FOAVip On the Computing Potential of Intracellular Vesicles ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=26431435 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26431435 #FOAvip English Wikipedia <ref>{{Cite pmid|26431435}}</ref> On the Computing Potential of Intracellular Vesicles #MMPMID26431435 Mayne R; Adamatzky A PLoS One 2015[]; 10 (10): ä PMID26431435show ga Collision-based computing (CBC) is a form of unconventional computing in which travelling localisations represent data and conditional routing of signals determines the output state; collisions between localisations represent logical operations. We investigated patterns of Ca2+-containing vesicle distribution within a live organism, slime mould Physarum polycephalum, with confocal microscopy and observed them colliding regularly. Vesicles travel down cytoskeletal ?circuitry? and their collisions may result in reflection, fusion or annihilation. We demonstrate through experimental observations that naturally-occurring vesicle dynamics may be characterised as a computationally-universal set of Boolean logical operations and present a ?vesicle modification? of the archetypal CBC ?billiard ball model? of computation. We proceed to discuss the viability of intracellular vesicles as an unconventional computing substrate in which we delineate practical considerations for reliable vesicle ?programming? in both in vivo and in vitro vesicle computing architectures and present optimised designs for both single logical gates and combinatorial logic circuits based on cytoskeletal network conformations. The results presented here demonstrate the first characterisation of intracelluar phenomena as collision-based computing and hence the viability of biological substrates for computing. äOn the Computing Potential of Intracellular Vesicles (epmc).pdf DeepDyve Pubget Overpricing