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10.1242/dev.114215

http://scihub22266oqcxt.onion/10.1242/dev.114215
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C4483763!4483763!26081571
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suck abstract from ncbi


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pmid26081571      Development 2015 ; 142 (12): 2094-108
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  • Orchestrating liver development #MMPMID26081571
  • Gordillo M; Evans T; Gouon-Evans V
  • Development 2015[Jun]; 142 (12): 2094-108 PMID26081571show ga
  • The liver is a central regulator of metabolism, and liver failure thus constitutes a major health burden. Understanding how this complex organ develops during embryogenesis will yield insights into how liver regeneration can be promoted and how functional liver replacement tissue can be engineered. Recent studies of animal models have identified key signaling pathways and complex tissue interactions that progressively generate liver progenitor cells, differentiated lineages and functional tissues. In addition, progress in understanding how these cells interact, and how transcriptional and signaling programs precisely coordinate liver development, has begun to elucidate the molecular mechanisms underlying this complexity. Here, we review the lineage relationships, signaling pathways and transcriptional programs that orchestrate hepatogenesis.
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