
| 10.1016/j.jsb.2016.05.003
http://scihub22266oqcxt.onion/10.1016/j.jsb.2016.05.003
 C6049083!6049083!27181417
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J+Struct+Biol 2016 ; 196 (1): 15-9 Nephropedia Template TP
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Organelle remodeling at membrane contact sites #MMPMID27181417Henne WMJ Struct Biol 2016[Oct]; 196 (1): 15-9 PMID27181417show ga
Cellular organelles must execute sophisticated biological processes to persist, and often communicate with one another to exchange metabolites and information. Recent studies suggest inter-organelle membrane contact sites (MCSs) are hubs for this cellular cross-talk. MCSs also govern membrane remodeling, thus controlling aspects of organelle shape, identity, and function. Here, we summarize three emerging phenomena that MCSs appear to govern: 1) organelle identity via the non-vesicular exchange of lipids, 2) mitochondrial shape and division, and 3) endosomal migration in response to sterol trafficking. We also discuss the role for ER-endolysosomal contact sites in cholesterol metabolism, and the potential biomedical importance this holds. Indeed, the emerging field inter-organellar cross-talk promises substantial advances in the fields of lipid metabolism and cell signaling.�
  
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