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10.1053/j.gastro.2015.12.042

http://scihub22266oqcxt.onion/10.1053/j.gastro.2015.12.042
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C4842135!4842135!26774180
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suck abstract from ncbi


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pmid26774180      Gastroenterology 2016 ; 150 (5): 1098-112
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  • Organoid Models of Human Gastrointestinal Development and Disease #MMPMID26774180
  • Dedhia PH; Bertaux-Skeirik N; Zavros Y; Spence JR
  • Gastroenterology 2016[May]; 150 (5): 1098-112 PMID26774180show ga
  • We have greatly advanced our ability to grow a diverse range of tissue-derived and pluripotent stem cell-derived gastrointestinal (GI) tissues in vitro. These systems, broadly referred to as organoids, have allowed the field to move away from the often non-physiologic, transformed cell lines that have been used for decades in GI research. Organoids are derived from primary tissues and have the capacity for long-term growth. They contain varying levels of cellular complexity and physiologic similarity to native organ systems. We review the latest discoveries from studies of tissue-derived and pluripotent stem cell-derived intestinal, gastric, esophageal, liver, and pancreatic organoids. These studies have provided important insights into GI development, tissue homeostasis, and disease and might be used to develop personalized medicines.
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