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10.1016/j.jss.2014.03.036 http://scihub22266oqcxt.onion/10.1016/j.jss.2014.03.036 C4225779!4225779!24742622     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=24742622&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24742622.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Surg+Res 2014 ; 190 (1): 55-63 Nephropedia Template TP {{tp|p=24742622|t=2014. Oridonin Inhibits Hepatic Stellate Cell Proliferation and Fibrogenesis |pdf=|usr=}}{{24742622}} gab.com Text Oridonin Inhibits Hepatic Stellate Cell Proliferation and Fibrogenesis JO: J Surg Res http://www.kidney.de/pget.php?&tw=1&pmid=24742622 #FOAvip Introduction: Liver fibrosis is a common response to liver injury and, in severe cases, leads to cirrhosis. The hepatic stellate cells (HSC) become activated after liver injury and play a significant role in fibrogenesis. The activated HSC is characterized by increased proliferation, overexpression of ?-smooth muscle actin (?-SMA), and excessive production of extracellular matrix (ECM) proteins. Oridonin, a naturally occurring diterpenoid, has been shown to induce apoptosis in liver and gastric cancer cells. However, its effects on HSC are unknown. Methods: We tested the effects of oridonin on the activated human and rat hepatic stellate cell lines LX-2 and HSC-T6 as well as the human hepatocyte cell line C3A. Transforming growth factor ?1 (TGF-?1) was used to stimulate LX-2 cells. Results: Oridonin significantly inhibited LX-2 and HSC-T6 proliferation. In contrast, Oridonin had no anti-proliferative effect on C3A cells at our tested range. Oridonin induced apoptosis and S phase arrest in LX-2 cells. These findings were associated with an increase in p53, p21, p16, and cleaved PARP, and with a decrease in Cdk4. Oridonin markedly decreased expression of ?-SMA and ECM protein type I collagen and fibronectin, blocked TGF-?1-induced Smad2/3 phosphorylation and type I Collagen expression. Conclusions: Oridonin induces apoptosis and cell cycle arrest involving the p53/p21 pathway in HSC, and appears to be non-toxic to hepatocytes. In addition, oridonin suppressed endogenous and TGF-?-induced ECM proteins. Thus, oridonin may act as a novel agent to prevent hepatic fibrosis. Twit Text FOAVip Oridonin Inhibits Hepatic Stellate Cell Proliferation and Fibrogenesis ????J Surg Res http://www.kidney.de/pget.php?&tw=1&pmid=24742622 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24742622 #FOAvip English Wikipedia <ref>{{Cite pmid|24742622}}</ref> Oridonin Inhibits Hepatic Stellate Cell Proliferation and Fibrogenesis #MMPMID24742622 Bohanon FJ; Wang X; Ding C; Ding Y; Radhakrishnan GL; Rastellini C; Zhou J; Radhakrishnan RS J Surg Res 2014[Jul]; 190 (1): 55-63 PMID24742622show ga Introduction: Liver fibrosis is a common response to liver injury and, in severe cases, leads to cirrhosis. The hepatic stellate cells (HSC) become activated after liver injury and play a significant role in fibrogenesis. The activated HSC is characterized by increased proliferation, overexpression of ?-smooth muscle actin (?-SMA), and excessive production of extracellular matrix (ECM) proteins. Oridonin, a naturally occurring diterpenoid, has been shown to induce apoptosis in liver and gastric cancer cells. However, its effects on HSC are unknown. Methods: We tested the effects of oridonin on the activated human and rat hepatic stellate cell lines LX-2 and HSC-T6 as well as the human hepatocyte cell line C3A. Transforming growth factor ?1 (TGF-?1) was used to stimulate LX-2 cells. Results: Oridonin significantly inhibited LX-2 and HSC-T6 proliferation. In contrast, Oridonin had no anti-proliferative effect on C3A cells at our tested range. Oridonin induced apoptosis and S phase arrest in LX-2 cells. These findings were associated with an increase in p53, p21, p16, and cleaved PARP, and with a decrease in Cdk4. Oridonin markedly decreased expression of ?-SMA and ECM protein type I collagen and fibronectin, blocked TGF-?1-induced Smad2/3 phosphorylation and type I Collagen expression. Conclusions: Oridonin induces apoptosis and cell cycle arrest involving the p53/p21 pathway in HSC, and appears to be non-toxic to hepatocytes. In addition, oridonin suppressed endogenous and TGF-?-induced ECM proteins. Thus, oridonin may act as a novel agent to prevent hepatic fibrosis. äOridonin Inhibits Hepatic Stellate Cell Proliferation and Fibrogenesis(epmc).pdf DeepDyve Pubget Overpricing