Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25632930.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Semin+Liver+Dis 2015 ; 35 (1): 3-11 Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Overview of MicroRNA Biology #MMPMID25632930
Mott JL; Mohr AM
Semin Liver Dis 2015[Feb]; 35 (1): 3-11 PMID25632930show ga
In considering an overview of microRNA biology, it is useful to consider microRNAs as a part of cellular communication. At the simplest level, microRNAs act to decrease the expression of mRNAs that contain stretches of sequence complementary to the microRNA. This function can be likened to the function of endogenous or synthetic short interfering RNA (siRNA). However, microRNA function is more complicated and nuanced than this ?on-off? model would suggest. Further, many microRNA targets are themselves non-coding RNAs. In this review, we will discuss the role of microRNAs in shaping the proteome of the cell in a way that is consistent with microRNA involvement in a highly regulated conversation, sensitive to outside influence and internal feedback.