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10.1016/j.tig.2017.04.005

http://scihub22266oqcxt.onion/10.1016/j.tig.2017.04.005
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C5608025!5608025!28528721
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suck abstract from ncbi


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pmid28528721      Trends+Genet 2017 ; 33 (7): 436-47
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  • Perspectives on Gene Regulatory Network Evolution #MMPMID28528721
  • Halfon MS
  • Trends Genet 2017[Jul]; 33 (7): 436-47 PMID28528721show ga
  • Animal development proceeds through the activity of genes and their cis-regulatory modules, working together in sets of gene regulatory networks (GRNs). Emergence of species-specific traits and novel structures results from evolutionary changes in GRNs. Recent work in a wide variety of animal models, and particularly in insects, has started to reveal the modes and mechanisms of GRN evolution. I discuss here different aspects of GRN evolution and argue that developmental system drift, in which conserved phenotype is nevertheless a result of changed genetic interactions, should regularly be viewed from the perspective of GRN evolution. Advances in methods to discover related cis-regulatory modules in diverse insect species, a critical requirement for detailed GRN characterization, are also described.
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