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10.1371/journal.pone.0199823 http://scihub22266oqcxt.onion/10.1371/journal.pone.0199823 C6025881!6025881!29958271     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29958271.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       PLoS+One 2018 ; 13 (6): ä Nephropedia Template TP {{tp|p=29958271|t=2018. Physiological random processes in precision cancer therapy |pdf=|usr=}}{{29958271}} gab.com Text Physiological random processes in precision cancer therapy JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=29958271 #FOAvip Many different physiological processes affect the growth of malignant lesions and their response to therapy. Each of these processes is spatially and genetically heterogeneous; dynamically evolving in time; controlled by many other physiological processes, and intrinsically random and unpredictable. The objective of this paper is to show that all of these properties of cancer physiology can be treated in a unified, mathematically rigorous way via the theory of random processes. We treat each physiological process as a random function of position and time within a tumor, defining the joint statistics of such functions via the infinite-dimensional characteristic functional. The theory is illustrated by analyzing several models of drug delivery and response of a tumor to therapy. To apply the methodology to precision cancer therapy, we use maximum-likelihood estimation with Emission Computed Tomography (ECT) data to estimate unknown patient-specific physiological parameters, ultimately demonstrating how to predict the probability of tumor control for an individual patient undergoing a proposed therapeutic regimen. Twit Text FOAVip Physiological random processes in precision cancer therapy ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=29958271 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29958271 #FOAvip English Wikipedia <ref>{{Cite pmid|29958271}}</ref> Physiological random processes in precision cancer therapy #MMPMID29958271 Henscheid N; Clarkson E; Myers KJ; Barrett HH PLoS One 2018[]; 13 (6): ä PMID29958271show ga Many different physiological processes affect the growth of malignant lesions and their response to therapy. Each of these processes is spatially and genetically heterogeneous; dynamically evolving in time; controlled by many other physiological processes, and intrinsically random and unpredictable. The objective of this paper is to show that all of these properties of cancer physiology can be treated in a unified, mathematically rigorous way via the theory of random processes. We treat each physiological process as a random function of position and time within a tumor, defining the joint statistics of such functions via the infinite-dimensional characteristic functional. The theory is illustrated by analyzing several models of drug delivery and response of a tumor to therapy. To apply the methodology to precision cancer therapy, we use maximum-likelihood estimation with Emission Computed Tomography (ECT) data to estimate unknown patient-specific physiological parameters, ultimately demonstrating how to predict the probability of tumor control for an individual patient undergoing a proposed therapeutic regimen. äPhysiological random processes in precision cancer therapy (epmc).pdf DeepDyve Pubget Overpricing