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10.1016/j.drudis.2016.06.020

http://scihub22266oqcxt.onion/10.1016/j.drudis.2016.06.020
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C5365153!5365153!27352632
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suck abstract from ncbi


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pmid27352632      Drug+Discov+Today 2016 ; 21 (9): 1540-52
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  • Physiologically Relevant Human Tissue Models for Infectious Diseases #MMPMID27352632
  • Mills M; Estes MK
  • Drug Discov Today 2016[Sep]; 21 (9): 1540-52 PMID27352632show ga
  • Limitations of animal infection models have engendered longstanding obstacles in basic science and translational research. Lack of suitable animal models, the need for better predictors of human immune responses, and pathogens that grow poorly or not at all outside the human host impact our ability to study infectious agents that cause human disease, generation of essential tools for genetic manipulation of microbial pathogens, and development of vaccines, therapeutics, and host-targeted immunotherapies. The advent of conceptual and methodological advances in tissue engineering along with collaborative efforts between the bioengineering and infectious diseases scientific communities holds great promise to overcome these significant barriers.



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