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10.1016/j.ceb.2016.03.002 http://scihub22266oqcxt.onion/10.1016/j.ceb.2016.03.002 C4887289!4887289!27015023     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27015023.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Curr+Opin+Cell+Biol 2016 ; 40 (ä): 81-9 Nephropedia Template TP {{tp|p=27015023|t=2016. Protein quality control in the nucleus |pdf=|usr=}}{{27015023}} gab.com Text Protein quality control in the nucleus JO: Curr Opin Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=27015023 #FOAvip The nucleus is the repository for the eukaryotic cell?s genetic blueprint, which must be protected from harm to ensure survival. Multiple quality control (QC) pathways operate in the nucleus to maintain the integrity of the DNA, the fidelity of the DNA code during replication, its transcription into mRNA, and the functional structure of the proteins that are required for DNA maintenance, mRNA transcription, and other important nuclear processes. Although we understand a great deal about DNA and RNA QC mechanisms, we know far less about nuclear protein quality control (PQC) mechanisms despite that fact that many human diseases are causally linked to protein misfolding in the nucleus. In this review, we discuss what is known about nuclear PQC and we highlight new questions that have emerged from recent developments in nuclear PQC studies. Twit Text FOAVip Protein quality control in the nucleus ????Curr Opin Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=27015023 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27015023 #FOAvip English Wikipedia <ref>{{Cite pmid|27015023}}</ref> Protein quality control in the nucleus #MMPMID27015023 Jones RD; Gardner RG Curr Opin Cell Biol 2016[Jun]; 40 (ä): 81-9 PMID27015023show ga The nucleus is the repository for the eukaryotic cell?s genetic blueprint, which must be protected from harm to ensure survival. Multiple quality control (QC) pathways operate in the nucleus to maintain the integrity of the DNA, the fidelity of the DNA code during replication, its transcription into mRNA, and the functional structure of the proteins that are required for DNA maintenance, mRNA transcription, and other important nuclear processes. Although we understand a great deal about DNA and RNA QC mechanisms, we know far less about nuclear protein quality control (PQC) mechanisms despite that fact that many human diseases are causally linked to protein misfolding in the nucleus. In this review, we discuss what is known about nuclear PQC and we highlight new questions that have emerged from recent developments in nuclear PQC studies. äProtein quality control in the nucleus (epmc).pdf DeepDyve Pubget Overpricing