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10.18632/oncotarget.8087 http://scihub22266oqcxt.onion/10.18632/oncotarget.8087 C4991368!4991368!26992231     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26992231.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Oncotarget 2016 ; 7 (15): 19099-110 Nephropedia Template TP {{tp|p=26992231|t=2016. RNA methyltransferase NSUN2 promotes stress-induced HUVEC senescence |pdf=|usr=}}{{26992231}} gab.com Text RNA methyltransferase NSUN2 promotes stress-induced HUVEC senescence JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=26992231 #FOAvip The tRNA methyltransferase NSUN2 delays replicative senescence by regulating the translation of CDK1 and CDKN1B mRNAs. However, whether NSUN2 influences premature cellular senescence remains untested. Here we show that NSUN2 methylates SHC mRNA in vitro and in cells, thereby enhancing the translation of the three SHC proteins, p66SHC, p52SHC, and p46SHC. Our results further show that the elevation of SHC expression by NSUN2-mediated mRNA methylation increased the levels of ROS, activated p38MAPK, thereby accelerating oxidative stress- and high-glucose-induced senescence of human vascular endothelial cells (HUVEC). Our findings highlight the critical impact of NSUN2-mediated mRNA methylation in promoting premature senescence. Twit Text FOAVip RNA methyltransferase NSUN2 promotes stress-induced HUVEC senescence ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=26992231 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26992231 #FOAvip English Wikipedia <ref>{{Cite pmid|26992231}}</ref> RNA methyltransferase NSUN2 promotes stress-induced HUVEC senescence #MMPMID26992231 Cai X; Hu Y; Tang H; Hu H; Pang L; Xing J; Liu Z; Luo Y; Jiang B; Liu T; Gorospe M; Chen C; Wang W Oncotarget 2016[Apr]; 7 (15): 19099-110 PMID26992231show ga The tRNA methyltransferase NSUN2 delays replicative senescence by regulating the translation of CDK1 and CDKN1B mRNAs. However, whether NSUN2 influences premature cellular senescence remains untested. Here we show that NSUN2 methylates SHC mRNA in vitro and in cells, thereby enhancing the translation of the three SHC proteins, p66SHC, p52SHC, and p46SHC. Our results further show that the elevation of SHC expression by NSUN2-mediated mRNA methylation increased the levels of ROS, activated p38MAPK, thereby accelerating oxidative stress- and high-glucose-induced senescence of human vascular endothelial cells (HUVEC). Our findings highlight the critical impact of NSUN2-mediated mRNA methylation in promoting premature senescence. äRNA methyltransferase NSUN2 promotes stress-induced HUVEC senescence (epmc).pdf DeepDyve Pubget Overpricing