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10.12688/f1000research.9764.1

http://scihub22266oqcxt.onion/10.12688/f1000research.9764.1
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C5642308!5642308!29098075
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suck abstract from ncbi


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pmid29098075      F1000Res 2016 ; 5 (�): �
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  • Recent advances in the management of migraine #MMPMID29098075
  • Obermann M; Holle D
  • F1000Res 2016[]; 5 (�): � PMID29098075show ga
  • Migraine remains one of the most disabling disorders worldwide. The high prevalence in the general population and the often-delicate treatment of patients account for that. Therapeutic management of migraine relies mainly on non-specific medical treatment and is affected by low patient adherence to the treatment regimens applied. The introduction of specific anti-migraine treatment occurred over 20 years ago when the first triptan was approved by regulatory authorities (sumatriptan, 28 December 1992). Triptan use is limited by side effects, time- and frequency-restricted application, and the risk of developing medication overuse headache. Within the past few years, new and promising drugs such as more specific 5-HT 1F receptor agonists (that is, lasmiditan) and monoclonal calcitonin gene-related peptide (CGRP) receptor antibodies entered advanced development phases while non-invasive neuromodulatory approaches were suggested to be potentially effective as non-pharmaceutical interventions for migraine.



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