Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26401268.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 F1000Res 2015 ; 4 (F1000 Faculty Rev): ä Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Recent developments in osteogenesis imperfecta #MMPMID26401268
Shaker JL; Albert C; Fritz J; Harris G
F1000Res 2015[]; 4 (F1000 Faculty Rev): ä PMID26401268show ga
Osteogenesis imperfecta (OI) is an uncommon genetic bone disease associated with brittle bones and fractures in children and adults. Although OI is most commonly associated with mutations of the genes for type I collagen, many other genes (some associated with type I collagen processing) have now been identified. The genetics of OI and advances in our understanding of the biomechanical properties of OI bone are reviewed in this article. Treatment includes physiotherapy, fall prevention, and sometimes orthopedic procedures. In this brief review, we will also discuss current understanding of pharmacologic therapies for treatment of OI.